Vapour-Phase Hydrogen Peroxide Pass Box
The most effective and economical way to introduce materials into your sterile production area
What is a VPHP Pass Box?
It is a machine designed to perform the low-temperature superficial bio-decontamination of materials using vaporized hydrogen peroxide (VHP).
What is a VPHP Pass Box used for?
It is used to introduce into sterile areas all those materials that cannot be sterilized in an autoclave, typically: heat sensitive products such as sterile petri-dishes; sterile materials for validation or cleaning activities, such as disinfectants; electronic particle meters; garments, etc. It is also widely use to decontaminate day-to-day production materials that cannot be processed by means of steam sterilization, such us rubber stopper bags and API aluminium containers.
10 c.m. chamber loading sidew
HEPA filters controls system
3 c.m. chamber flush floor design
3.5 c.m. chamber - movable shelves design
2 c.m. chamber pre-sterile side view
How does a VPHP Pass Box work?
A built-in VPHP generator heats up the hydrogen peroxide, converting it from liquid to vapour. This is then blown into the chamber, creating a lethal environment capable of killing bacteria, viruses and fungi. Each step of the process is fully controlled, guaranteeing perfect performance over time.
Why use vaporized H2O2 instead of spray systems?
Ninety percent of worldwide pharmaceutical production plants use vaporized H2O2. There are many reasons why simple spray o micronized systems have not become popular. Vapour is indicated for a wide range of microorganisms and guarantees uniform distribution, reaching the most critical areas of the chamber. It is capable of achieving 6-log reduction on all exposed surfaces, avoiding the potential creation of a Biofilm. The chemical and physical properties of vaporized hydrogen peroxide (VHP) are compatible with most of the materials used in sterile production areas. Moreover, vapour limits the formation of potentially corrosive liquids, which normally occurs with other spray systems.
How is a VPHP Pass Box made?
Our machine consists of an airtight stainless steel chamber in which the operator introduces the products to be decontaminated. The components required to control each critical parameter throughout the cycle are all installed in the technical compartment. Our extensive skills and know-how in the manufacturing of machinery ensure the absolute competitiveness of our VPHP Pass Box with regard to initial investment, operating costs and process repeatability.
Will the machine fit into my clean room?
All our machines can be fully customized to suit the customer’s needs, for example with regard to flexible chamber dimensions, location of the technical compartment, and tailored baskets.
Main technical features
- Fully-welded AISI 304 frame
- AISI 316L chamber with an interior mirror polished finish (r.a. < 0.3 microns)
- Chamber capacity of 500- 5,000 litres
- Internal chamber with rounded angles (R = 30, 40 or 60 mm)
- External satin or mirror polished finish
- Doors with inflatable gaskets and large window
- Trolley + basket solutions or flush floor design
- Bioreset Pro® open-loop generator controlled via modbus
- Dedicated air handling unit for de-aeration
- Dedicated air pre-conditioning unit with self-regenerating dehumidifier
- Dräger sensors to control process parameters
- Panel PC solution running on iFIX operating system
- CFR 21 annex 11 compliance